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Burkhard Luy
Prof. Dr. Burkhard Luy

 

Professur für Bioanalytik
Institut für Organische Chemie
Fritz-Haber-Weg 6
76131 Karlsruhe
Deutschland

    
Direktor
Institut für Biologische Grenzflächen 4
Magnetische Resonanz
Postfach 3640
D-76021 Karlsruhe
 

Curriculum Vitae

 

Sekretariat / Secretary

Janine Moritz

Institut für Biologische Grenzflächen 4
Magnetische Resonanz
Postfach 3640
D-76021 Karlsruhe

Tel.: +49 721 608 29360

 

Joint project

 


 

News

Poster Award Euromar 2017

Herzlich Willkommen / Welcome

gruppenbild

Our research is focused on Magnetic Resonance, the only technique to solve structure and dynamics of molecules at atomic resolution in solution. We are interested both in methods development and application. The highly interdisciplinary method development comprises theory and experiment, involving equally quantum mechanical simulations and optimizations based on principles of optimal control theory, cognitive design of overall rf-pulse sequences to address specific measurement tasks, the development of special sample preparation procedures, and the design of hardware extensions. Questions regarding data interpretation are addressed by computational chemical approaches, including basic spectroscopic rules and simple alignment-tensor approaches as well as sophisticated molecular dynamics approaches with magnetic resonance-derived constraints and quantum chemical calculations. We apply NMR spectroscopy to solve interesting/important questions in chemistry, biology, material science and medicine.

More detailed information can be found in Research .

We are always looking for master and PhD students. Especially students with a strong background in either chemistry, physics, or mathematics are highly encouraged to apply. See the website angebotene Positionen for details. Specific projects for master theses can be found here.

 

Recent Publications

J. Haller, A. Bodor, B. Luy, "Real-time pure shift measurements for uniformly isotope-labeled molecules using X-selective BIRD homonuclear decoupling.", J. Magn. Reson 302, 64-71 (2019).

A. Götz, P. Högel, M. Silber, I. Chaitoglou, B. Luy, C. Muhle-Goll, C. Scharnagl, D. Langosch, "Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP", Scientific Reports 9, 5321 (2019).

A. Götz, N. Mylonas, P. Högel, M. Silber, H. Heinel, S. Menig, A. Vogel, H. Feyrer, D. Huster, B. Luy, D. Langosch, C. Scharnagl, C. Muhle-Goll, F. Kamp, H. Steiner, "Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage", Biophysical Journal 116 (11), 2103-2120 (2019).

 A. Hauser, P. Eisenmann, C. Muhle-Goll, B. Luy, A. Dötsch, D. Graf, P. Tzvetkova, "Efficient Extraction from Mice Feces for NMR Metabolomics Measurements with Special Emphasis on SCFAs" Metabolites 9 (3), 55 (2019).

M.R.M. Koos, B.Luy, "Polarization recovery during ASAP and SOFAST/ALSOFAST-Type Experiments", Journal of Magnetic Resonance 300, 61-75 (2019).

J. Becker, M.R.M. Koos, D. Schulze Sünninghausen, B.Luy, "ASAP-HSQC-TOCSY for Fast Spin System Identification and Extraction of Long-Range Couplings", Journal of Magnetic Resonance 300, 76-83 (2019).