Photodamages in DNA

DNA is continuously exposed to solar UV radiation and other light sources, which can induce a variety of photolesions associated with mutagenesis, aging, and disease. Our research focuses on the molecular mechanisms underlying DNA photodamage, including both direct excitation of DNA and indirect pathways mediated by photosensitizers.

We investigate the photochemical and photophysical processes induced by endogenous and exogenous photosensitizers, with particular emphasis on naturally occurring chromophores and modified nucleosides, including 5-formyluridine (fdU), xanthone, and thioxanthone derivatives. Using spectroscopic, photochemical, and theoretical approaches, we study how energy and electron transfer processes contribute to the formation of DNA lesions and oxidative damage.

Our goal is to achieve a detailed mechanistic understanding of DNA photodamage and its implications for photobiology, photomedicine, and radiation-induced biological effects.