My research is focussed on structural biology and metabolomics to solve questions in molecular biology and medicine by Nuclear Magnetic Resonance. In parallel, we additionally employ a diverse range of biochemical, biomolecular and bioinformatics techniques to develop a comprehensive understanding of the studied systems. To understand cellular processes on a molecular level the 3D structures of the respective proteins have to be known. NMR spectroscopy is a versatile technique both for elaborate structure determination and for fast interaction studies e.g. for ligand screening. We have studied a diverse range of proteins with the aim to understand how protein function is related to structure and dynamics. Current main activities of my lab centre on the interplay between structure and dynamics of transmembrane helices and on the function of Bag1, a molecular chaperone regulator that is involved in prostate cancer regulation.
Metabolomics studies evolved as second key aspect of my lab in recent years. Here we aim to establish NMR spectroscopy as a diagnostic tool e. g. for the detection of acute or permanent kidney failure in collaboration with the university hospital Heidelberg or the clinics at Karlsruhe.
since 10/2010 Group Leader biological NMR spectroscopy, Institute for biological interfaces 4
2011 – 2013 Privatdozent for Biochemistry and Biophysics, Heidelberg university, Germany
2007 – 2010 Group Leader liquid state NMR spectroscopy, Institute for biological interfaces 2
2004 – 2007 Emmy-Noether Junior Research Group Leader Max-Planck-Institute for medical research Heidelberg, Germany and team leader EMBL Heidelberg, Germany
2000 – 2004 Emmy-Noether Junior Research Group Leader university clinic Mannheim, Germany and team leader EMBL Heidelberg, Germany
1999 – 2000 Postdoc at the EMBL Heidelberg, Germany with Dr. Michael Nilges
1996 – 1998 Postdoc at the Institute de Biologie Structurale, Grenoble, France with Dr. Dominique Marion
Scientific Activities, Honors, Awards
present Member of the German Society of Chemists (NMR subgroup)
2000 – 2007 Emmy-Noether-Fellowship of the DFG (German National Funding Agency)
1996-1998 EMBO Postdoctorate Grant
1992-1996 EMBL Predoctorate Grant