Hybrid-Lecture (in person + online)

Wednesdays 14:00-15:30, Seminar Room SR 201, Geb. 30.42 (Organische Chemie), 2. OG., 7 lecture units

First lecture: 4. Nov 2026, then the following lectures on: 11. Nov., 18. Nov., 25.Nov., 2. Dec., 9. Dec, 16. Dec. 2026, (13. Jan. 2026 as a backup date)

the lecture slides will be available for download shortly before the respective lecture.

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The Zoom link will be available here shortly before the start of the lecture (beginning November 2026)

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This interdisciplinary course on the interface of organic chemistry, chemical, molecular and synthetic biology aims to provide the current status of research on the following topics:

Artificial genetic polymers and oligonucleotide analogues; unnatural base pairing – expansion of the genetic alphabet;

artificial ribozymes for efficient catalysis and recognition (SELEX, DNAzymes, foldamers);

biosynthetic incorporation of unnatural aminoacids (UAAs) into proteins;

protein engineering – production of enzymes with unknown or unnatural properties, ab initio protein design, directed evolution, theozymes;

Artificial lipid vesicles as models for protocell multiplication;

This lecture will be continued in SoSe2027 as a course "The molecular origins of life", focused on processes which could allow abiotic generation of biomolecules (aminoacids, lipids, nucleotides, sugars) on the early Earth for the following origin of life.