Hybrid-Lecture (in person + online)

Wednesdays 14:00-15:30, Seminar Room SR 201, Geb. 30.42 (Organische Chemie), 2. OG., 7 lecture units

First lecture: 29. Oct. 2025, then the following lectures on: 12. Nov., 19. Nov., 26. Nov., 3. Dec., 10. Dec and 17. Dec, (eventual backup date 7. Jan. 2026)

the lecture slides will be available for download shortly before the respective lecture.

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To join the lecture as a Zoom meeting, please click on the following link:

https://us02web.zoom.us/j/81927185504?pwd=bw1P5JPB3ELwcWPCaLmhshPlZT6d0d.1

Meeting ID: 819 2718 5504
Access code: 050961

This interdisciplinary course on the interface of organic chemistry, chemical, molecular and synthetic biology aims to provide the current status of research on the following topics:

Artificial genetic polymers and oligonucleotide analogues; unnatural base pairing – expansion of the genetic alphabet;

artificial ribozymes for efficient catalysis and recognition (SELEX, DNAzymes, foldamers);

biosynthetic incorporation of unnatural aminoacids (UAAs) into proteins;

protein engineering – production of enzymes with unknown or unnatural properties, ab initio protein design, directed evolution, theozymes;

Artificial lipid vesicles as models for protocell multiplication;

This lecture will be continued in SoSe2026 as a course "The molecular origins of life", focused on processes which could allow abiotic generation of biomolecules (aminoacids, lipids, nucleotides, sugars) on the early Earth for the following origin of life.