Pianowski Group

The Molecular Origins of Life SoSe 2019 KIT

  • Typ:
  • Ort:

    Seminar room SR 201, Geb 30.42, IOC KIT

  • Zeit:

    Wednesdays, 14:00-15:30, weekly from 15.05.2019

  • SWS: 1 SWS
  • Hinweis:

    Lecture dates: weekly from 15th May 2019 

    Lecture time: Wednesdays, 14:00-15:30, Seminarraum 201, 2. OG, IOC KIT, Geb 30.42

    Following topics will be discussed:

    Definitions of life – e.g. self-replicating chemical systems that use external energy sources to stay out of the equilibrium;

    The origin of atoms and simple molecules - how the Universe, stars, planets, and molecules building them were formed?

    Minimal requirements for a habitable environment – under which conditions the known forms of life can exist? Hypothetical other chemistries that could form living systems elsewhere;

    The primordial soup – what pool of biologically relevant molecules likely existed on the prebiotic Earth: the Miller-Urey experiment, the formose reaction, prebiotic syntheses of aminoacids, sugars, nucleic acids, nucleotides, and lipids, prebiotic polymerization;

    The origin of life – self-replicating systems, metabolism-first vs. gene-first, the “RNA world”, the origins of homochirality;

    Formation of protocells – enhancing RNA with polypeptides, establishment of the genetic code, DNA as the enhanced information storage, metabolic networks, membranes;

    From molecules to cells – LUCA (Last Universal Common Ancestor), information storage and function – split on different molecules, origins of the genetic code, metabolic networks and lipid membranes;

    The history of life on Earth – timeline for LUCA, beginning of photosynthesis and aerobic metabolism, Eukaryotes, multicellular life, extremophilic organisms, habitable worlds outside Earth – current status of knowledge, space exploration programs;